Why the study?
Do specific bile acids induce arrhythmias in human atrial myocardium and correlate with atrial fibrillation?
Do specific bile acids induce arrhythmias in human atrial myocardium and correlate with atrial fibrillation?
Altered serum bile acid composition, characterized by high arrhythmogenic and low protective bile acids, may decrease the arrhythmic threshold and facilitate atrial fibrillation.
Answers are grounded in this paper and cite their sources.
May lower arrhythmic threshold in AF; hypothesis-generating for bile acid modulation pending human trials.
High TCA concentrations induce arrhythmias in adult human atria while ursodeoxycholic acid does not. AF is associated with higher serum levels of non-ursodeoxycholic bile acid conjugates and low levels of ursodeoxycholic acid conjugates. These data suggest that higher levels of toxic (arrhythmogenic) and low levels of protective bile acids create a milieu with a decreased arrhythmic threshold and thus may facilitate arrhythmic events.
No takes yet. Share an insight, caveat, or question.
Rainer et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: