What question did this study set out to answer?

To engineer a flexible bioelectronic device capable of rolling into a needle for minimally invasive insertion and expanding into a broad paddle electrode at the spinal target site.

June 25, 2021Science AdvancesOpen Access

Electronics with shape actuation for minimally invasive spinal cord stimulation

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Authors

BWBen J. WoodingtonUniversity of Cambridge VCVincenzo F. CurtoUniversity of Cambridge YYYi-Lin YuTri-Service General Hospital

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Overview

Experimental study demonstrates minimally invasive implantation of shape-expanding paddle electrodes in cadaver models, suggesting a path toward less invasive neuromodulation therapies.

Key Points

To engineer a flexible bioelectronic device capable of rolling into a needle for minimally invasive insertion and expanding into a broad paddle electrode at the spinal target site.
Fabricated thin, flexible electronic arrays with integrated fluidic channels using photo- and soft lithography.
Evaluated device rolling, percutaneous needle delivery, and fluid-driven in situ expansion using in vitro systems and human cadaver models.
Engineered an electronic device that compacts into the diameter of a standard percutaneous needle and successfully unfurls into a paddle-type conformation upon fluid actuation.
Achieved successful needle-based percutaneous implantation and subsequent expansion within spinal spaces in human cadavers without open surgical cutdowns.

Cite This Study

Woodington et al. (2021) studied this question.

synapsesocial.com/papers/69d7782cb843b2be9948fe98 https://doi.org/10.1126/sciadv.abg7833

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June 25, 2021Science AdvancesOpen Access

Electronics with shape actuation for minimally invasive spinal cord stimulation

View Full Paper

Ask AI

Bookmark

Authors

BWBen J. WoodingtonUniversity of Cambridge VCVincenzo F. CurtoUniversity of Cambridge YYYi-Lin YuTri-Service General Hospital

Discussion

Member takes

Overview

Experimental study demonstrates minimally invasive implantation of shape-expanding paddle electrodes in cadaver models, suggesting a path toward less invasive neuromodulation therapies.

Key Points

To engineer a flexible bioelectronic device capable of rolling into a needle for minimally invasive insertion and expanding into a broad paddle electrode at the spinal target site.
Fabricated thin, flexible electronic arrays with integrated fluidic channels using photo- and soft lithography.
Evaluated device rolling, percutaneous needle delivery, and fluid-driven in situ expansion using in vitro systems and human cadaver models.
Engineered an electronic device that compacts into the diameter of a standard percutaneous needle and successfully unfurls into a paddle-type conformation upon fluid actuation.
Achieved successful needle-based percutaneous implantation and subsequent expansion within spinal spaces in human cadavers without open surgical cutdowns.

Cite This Study

Woodington et al. (2021) studied this question.

synapsesocial.com/papers/69d7782cb843b2be9948fe98 https://doi.org/10.1126/sciadv.abg7833

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