What question did this study set out to answer?

To elucidate the evolutionary and genetic mechanisms driving commensal gut Escherichia coli to become systemic avian pathogenic strains in poultry.

February 3, 2021SHILAP Revista de lepidopterologíaOpen Access

Genome evolution and the emergence of pathogenicity in avian Escherichia coli

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Authors

LMLeonardos MageirosNational and Kapodistrian University of Athens GMGuillaume MéricUppsala University SBSion BaylissUniversity of Bristol

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Implication

Comparative genomic study uncovers multi-gene drivers of extraintestinal infection in poultry, indicating that machine learning can identify emerging pathogenic strains in healthy flocks.

Key Points

To elucidate the evolutionary and genetic mechanisms driving commensal gut Escherichia coli to become systemic avian pathogenic strains in poultry.
Conducted population-scale comparative genomics and pangenome-wide association studies comparing commensal carriage isolates with systemic infection isolates.
Trained a Random Forest machine learning classification model to distinguish carriage from disease strains and predict pathogenic status in the emergent ST-117 lineage.
Identified pathogenicity-associated variations across 143 genes linked to metabolism, lipopolysaccharide synthesis, heat shock response, toxicity, and antimicrobial resistance, primarily distributed via horizontal gene transfer.
A Random Forest model achieved 73% accuracy in predicting pathogenic disease status from carriage in the emergent ST-117 poultry lineage.

Cite This Study

Mageiros et al. (2021) studied this question.

synapsesocial.com/papers/69d77c51b843b2be9948ff7a https://doi.org/10.1038/s41467-021-20988-w

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Implication

Comparative genomic study uncovers multi-gene drivers of extraintestinal infection in poultry, indicating that machine learning can identify emerging pathogenic strains in healthy flocks.

Genome evolution and the emergence of pathogenicity in avian Escherichia coli

Discussion

Member takes

Implication

Key Points

Cite This Study

Genome evolution and the emergence of pathogenicity in avian Escherichia coli

Discussion

Member takes

Implication

Key Points

Cite This Study

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