After myocardial infarction, TGF-β1 signaling drives global left ventricular fibroblast activation, but localized regional signaling is required for further maturation and extracellular matrix remodeling.
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Localized signals beyond TGF-β1 may drive post-MI fibrosis; hypothesis-generating for regional remodeling mechanisms in animal models.
Nagaraju et al. (2017) studied this question.
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