What question did this study set out to answer?

To review the contribution of oxidative stress to neurodegeneration and evaluate upstream and downstream antioxidant therapeutic mechanisms for mitigating neuronal damage.

March 1, 2009Current NeuropharmacologyOpen Access

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

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To review the contribution of oxidative stress to neurodegeneration and evaluate upstream and downstream antioxidant therapeutic mechanisms for mitigating neuronal damage.
Synthesized molecular mechanisms linking aerobic metabolism, reactive oxygen species generation, and endogenous antioxidant defenses to neurodegenerative disorders.
Evaluated upstream and downstream interventions, including dietary sources and medicinal herbs, for free radical scavenging and metal ion sequestration capabilities.
Overproduction of reactive oxygen species overwhelms endogenous defenses, precipitating protein and DNA injury, neuroinflammation, tissue damage, and cellular apoptosis in Alzheimer's and Parkinson's diseases.
Upstream antioxidant strategies effectively sequester metal ions involved in neuronal plaque formation, whereas downstream therapies scavenge reactive oxygen species to mitigate post-stress neurodegeneration.

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Implication

Review demonstrates the protective efficacy of antioxidant therapies in neurodegenerative diseases, highlighting their potential to sequester metal ions and neutralize oxidative neuronal damage.

Cite This Study

Uttara et al. (2009) studied this question.

synapsesocial.com/papers/69d77e58aa68b335b4f31c4a https://doi.org/10.2174/157015909787602823

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Implication

Review demonstrates the protective efficacy of antioxidant therapies in neurodegenerative diseases, highlighting their potential to sequester metal ions and neutralize oxidative neuronal damage.

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

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Discussion

Implication

Cite This Study

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

Key Points

Discussion

Implication

Cite This Study

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