Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization–Recommended Weight Band Doses and Formulations

Chishala Chabala; Anna Turkova; Anneke C. Hesseling; Kevin Zimba; Marieke van der Zalm; Monica Kapasa; Megan Palmer; Maxwell Chirehwa; Lubbe Wiesner; Eric Wobudeya; Aarti Kinikar; Vidya Mave; Syed Hissar; Louise Choo; Kristen LeBeau; Veronica Mulenga; R. A. Aarnoutse; Diana M. Gibb; Helen McIlleron

doi:10.1093/cid/ciab725

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Abstract

Recommended weight band-based FDC doses result in lower drug exposures in children in lower weight bands and in those ≥25 kg (receiving adult doses). Further adjustments to current doses are needed to match current target exposures in adults. The use of ethambutol at the current World Health Organization-recommended doses requires further evaluation.

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Chabala et al. (2021) studied this question.

synapsesocial.com/papers/69d77eaedb9d5e1bf4b8b21c https://doi.org/10.1093/cid/ciab725

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Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization–Recommended Weight Band Doses and Formulations

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Pharmacokinetics of First-Line Drugs in Children With Tuberculosis, Using World Health Organization–Recommended Weight Band Doses and Formulations

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