Summary A bidirectional relation between depressive disorders and epilepsy has been suggested by several population‐based studies and is supported by experimental studies. This article reviews the potential pathogenic mechanisms operant in both disorders that may explain such a relation. These mechanisms include a hyperactive hypothalamic–pituitary–adrenal (HPA) axis and its neuroanatomic and neuropathologic complications, as well as disturbances in serotonergic, noradrenergic, γ‐aminobutyric acid (GABA)ergic and glutamatergic neurotransmitter systems, all of which may be interrelated.
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Andrés M. Kanner (2011) studied this question.
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