What question did this study set out to answer?

To review the synthesis, functional diversity, and medicinal chemistry applications of the most prevalent sulfur-containing scaffolds in pharmaceutical development.

March 3, 2016Current Topics in Medicinal ChemistryOpen Access

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

View Full Paper

Ask AI

Bookmark

To review the synthesis, functional diversity, and medicinal chemistry applications of the most prevalent sulfur-containing scaffolds in pharmaceutical development.
Analyzed the structural characteristics and clinical integration of sulfur moieties across 362 FDA-approved pharmaceuticals.
Surveyed modern synthetic methodologies for constructing core sulfur-based functional groups, focusing on sulfonamides, thioethers, sulfones, and penicillin derivatives.
Identified sulfur as the predominant heteroatom behind oxygen and nitrogen in approved pharmacotherapies, incorporated into 362 FDA-approved drugs.
Summarized recent advances in synthetic pathways and functional applications for four major sulfur pharmacophores: sulfonamides, thioethers, sulfones, and penicillin cores.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Review outlines synthetic advances and applications of sulfur-containing drug scaffolds, highlighting their presence across 362 approved therapeutics.

Cite This Study

Feng et al. (2016) studied this question.

synapsesocial.com/papers/69d7814bf44a16d01ef318f4 https://doi.org/10.2174/1568026615666150915111741

View Full Paper

Ask AI

Bookmark

Implication

Review outlines synthetic advances and applications of sulfur-containing drug scaffolds, highlighting their presence across 362 approved therapeutics.

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Key Points

Discussion

Implication

Cite This Study

Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider