March 9, 1999Circulation
Selective Potentiation of Peripheral Chemoreflex Sensitivity in Obstructive Sleep Apnea
Why the study?
Is Obstructive Sleep Apnea associated with altered autonomic, hemodynamic, and ventilatory responses to peripheral chemoreceptor activation by hypoxia?
Population
Patients with Obstructive Sleep Apnea (OSA)
Design
Other
Authors
Discussion
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Member takes
Implication
May explain excess CV risk in OSA; leaves open whether chemoreflex modulation improves outcomes.
Structured PICO
Is Obstructive Sleep Apnea associated with altered autonomic, hemodynamic, and ventilatory responses to peripheral chemoreceptor activation by hypoxia?
P
Population
Patients with Obstructive Sleep Apnea (OSA)
I
Intervention
Peripheral chemoreceptor activation by hypoxia
O
Outcome
Autonomic, hemodynamic, and ventilatory responsessurrogate
OSA selectively potentiates physiological responses to hypoxia, highlighting a potential mechanism for cardiovascular risk in these patients.
Cite This Study
Narkiewicz et al. (1999) studied this question.