Observational study reveals gut microbiome alterations in proton pump inhibitor users, highlighting potential mechanisms behind increased susceptibility to enteric infections.
The differences between PPI users and non-users observed in this study are consistently associated with changes towards a less healthy gut microbiome. These differences are in line with known changes that predispose to C. difficile infections and can potentially explain the increased risk of enteric infections in PPI users. On a population level, the effects of PPI are more prominent than the effects of antibiotics or other commonly used drugs.
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Imhann et al. (2015) studied this question.
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