What question did this study set out to answer?

To systematically review how the epidemiology of human monkeypox has evolved over time, focusing on case counts, patient age, mortality, and geographic distribution.

February 11, 2022SHILAP Revista de lepidopterologíaOpen Access

The changing epidemiology of human monkeypox—A potential threat? A systematic review

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To systematically review how the epidemiology of human monkeypox has evolved over time, focusing on case counts, patient age, mortality, and geographic distribution.
Registered systematic review protocol with PROSPERO (CRD42020208269).
Screened and extracted data from 48 peer-reviewed articles and 18 grey literature sources.
Assessed confirmed, probable, and possible cases, age at presentation, and clade-specific case fatality rates across geographic regions since the 1970s.
Human monkeypox incidence increased substantially since the 1970s, with the largest increases in the Democratic Republic of the Congo, while median age of presentation shifted from 4 years (1970s) to 21 years (2010–2019).
The pooled case fatality rate was 8.7% overall, with mortality significantly higher for the Central African clade at 10.6% (95% CI: 8.4%–13.3%) compared to the West African clade at 3.6% (95% CI: 1.7%–6.8%).
International travel- and import-related events led to recurrent outbreaks beyond endemic African nations, driven by contact with infected animals or humans amid declining smallpox vaccination.

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Implication

Systematic review reveals rising monkeypox cases and increasing patient age globally, indicating waning cross-protective immunity.

Cite This Study

Bunge et al. (2022) studied this question.

synapsesocial.com/papers/69d78f03d84d071b73f30835 https://doi.org/10.1371/journal.pntd.0010141

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The changing epidemiology of human monkeypox—A potential threat? A systematic review

Key Points

Discussion

Implication

Cite This Study

The changing epidemiology of human monkeypox—A potential threat? A systematic review

Key Points

Discussion

Implication

Cite This Study

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