What question did this study set out to answer?

To determine whether transgenic mice expressing mutant human amyloid precursor protein develop progressive memory impairments alongside amyloid-beta accumulation and neuropathology.

October 4, 1996Science

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Authors

KHKaren HsiaoUniversity of Minnesota PCPaul F. ChapmanCentre National de la Recherche Scientifique SNSteven P. NilsenBrigham and Women's Hospital

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Implication

Transgenic mouse study demonstrates age-dependent memory deficits accompanied by amyloid-beta elevation and plaque deposition, suggesting a viable model for Alzheimer's disease pathology.

Key Points

To determine whether transgenic mice expressing mutant human amyloid precursor protein develop progressive memory impairments alongside amyloid-beta accumulation and neuropathology.
Assessed transgenic mice overexpressing human APP695 with the Lys670-->Asn, Met671-->Leu mutation across spatial reference and alternation tasks at 3 months versus 9 to 10 months of age.
Quantified cerebral Aβ(1-40) and Aβ(1-42/43) concentrations and evaluated cortical and limbic amyloid plaque deposition using Congo red histological staining.
Mice showed preserved spatial learning and memory performance at 3 months but developed notable memory deficits by 9 to 10 months of age.
Cognitive decline coincided with a 5-fold increase in Aβ(1-40) and a 14-fold increase in Aβ(1-42/43) levels.
Abundant Congo red-positive amyloid plaques deposited in the cortical and limbic regions of mice exhibiting elevated amyloid levels.

Cite This Study

Hsiao et al. (1996) studied this question.

synapsesocial.com/papers/69d79166a863640d1fb8a3f6 https://doi.org/10.1126/science.274.5284.99

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Implication

Transgenic mouse study demonstrates age-dependent memory deficits accompanied by amyloid-beta elevation and plaque deposition, suggesting a viable model for Alzheimer's disease pathology.

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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