Why the study?
Does evening administration of antihypertensive medications reduce morning blood pressure surge in hypertensive patients?
Does evening administration of antihypertensive medications reduce morning blood pressure surge in hypertensive patients?
Evening administration of antihypertensives is more effective than morning dosing at reducing morning blood pressure surges without increasing adverse events, though hard clinical endpoint data is still needed.
Evening dosing may be preferred to blunt morning BP surge without added risk; extends chronotherapy data but leaves hard outcomes open.
Our study suggested that evening administration of antihypertensive medications exerted better blood pressure-lowering effect on MBPS compared with conventional morning dosage. Safety assessment also indicated that the evening regimen did not increase the risk of adverse events. However, endpoint studies need to be carried out to confirm the significance and feasibility of this treatment regimen in clinical practice.
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Xie et al. (2021) studied this question.
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