Sarcopenia in the Older Adult With Cancer

Article Tools REVIEW ARTICLES Caring for Older Adults With Cancer Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.21.00102 Journal of Clinical Oncology - published online before print May 27, 2021 PMID: 34043430 Sarcopenia in the Older Adult With Cancer Grant R. Williams , MD, MSPH1,2xGrant R. WilliamsSearch for articles by this author; Richard F. Dunne , MD3xRichard F. DunneSearch for articles by this author; Smith Giri , MD, MHS1,2xSmith GiriSearch for articles by this author; Shlomit S. Shachar , MD4,5xShlomit S. ShacharSearch for articles by this author; and Bette J. Caan, DrPH6xBette J. CaanSearch for articles by this author Show More 1Institute for Cancer Outcomes & Survivorship, University of Alabama at Birmingham, Birmingham, AL2Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL3Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY4Department of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel5Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel6Division of Research, Kaiser Permanente, Oakland, CA https://doi.org/10.1200/JCO.21.00102 First Page Full Text PDF Figures and Tables © 2021 by American Society of Clinical OncologyCONTEXTKey ObjectiveWhat is sarcopenia and why is it important in older adults with cancer?Knowledge GeneratedOlder adults with cancer are at increased risk of sarcopenia, and in turn, increased risk of chemotherapy toxicities, tumor progression, and mortality. Sarcopenia can be assessed using a variety of available methods and individuals with sarcopenia may benefit from targeted interventions consisting of exercise and/or nutrition.RelevanceDetecting sarcopenia in the growing number of older adults with cancer can aid in the assessment of the risk and benefit ratio of cancer treatments and assist in targeting interventions. Still, many important knowledge gaps persist in our understanding of sarcopenia in oncology and more research is needed.SUPPORTSupported in part by the National Cancer Institute of the National Institutes of Health (Grant No. K08CA234225, G.R.W.), the American Cancer Society (Grant No. ACS-18-162-59-IRG, G.R.W.) and the National Center for Advancing Translational Sciences of the National Institutes of Health (Grant No. KL2TR001999, R.F.D.).