Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS

Toshiyuki Sakaeda; Kaori Kadoyama; Hiroaki Yabuuchi; Satoshi Niijima; Kyoko Seki; Yukinari Shiraishi; Yasushi Okuno

doi:10.7150/ijms.8.332

January 1, 2011International Journal of Medical SciencesOpen Access

Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS

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Key Points

Assess the utility of optimized data mining algorithms in identifying and validating associations between platinum chemotherapeutic agents and hypersensitivity reactions using spontaneous report data.
Extracted adverse drug reaction records from the public version of the FDA Adverse Event Reporting System (AERS).
Applied optimized pharmacovigilance data mining algorithms to detect and quantify safety signals related to platinum-induced hypersensitivity.
Identified clear pharmacovigilance signals linking platinum-based chemotherapy agents with hypersensitivity reactions.
Confirmed that optimized data mining tools within spontaneous reporting databases can effectively characterize and track adverse drug reaction profiles.

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Implication

Pharmacovigilance analysis demonstrates associations between platinum agents and hypersensitivity reactions in treated patients, highlighting the utility of surveillance data mining.

Abstract

The FDA's adverse event reporting system, AERS, with optimized data mining tools is useful to authorize potential associations between platinum agents and hypersensitivity reactions.

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Sakaeda et al. (2011) studied this question.

synapsesocial.com/papers/69d7c452f39344339dd180ad https://doi.org/10.7150/ijms.8.332

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Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS

Key Points

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Implication

Abstract

Discussion

Cite This Study

Platinum Agent-Induced Hypersensitivity Reactions: Data Mining of the Public Version of the FDA Adverse Event Reporting System, AERS

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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