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April 25, 2012Environmental Health PerspectivesOpen Access

PCB-95 Modulates the Calcium-Dependent Signaling Pathway Responsible for Activity-Dependent Dendritic Growth

Gary A. Wayman Diptiman D. Bose Dongren Yang Atom J. Lesiak Donald A. Bruun Soren Impey Veronica A. Ledoux Isaac N. Pessah Pamela J. Lein

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Abstract

RyR activity contributes to dynamic remodeling of dendritic architecture in response to NDL PCBs via CaMKI-CREB-Wnt2 signaling in rats. Our findings identify PCBs as candidate environmental risk factors for neurodevelopmental disorders, especially in children with heritable deficits in calcium signaling associated with autism.

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Wayman et al. (2012) studied this question.

synapsesocial.com/papers/69d7c4e93b601d7be3ae2c97 https://doi.org/10.1289/ehp.1104833

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