Population
Skeletal sarcoplasmic reticulum (SR) fused with bilayer lipid membranes (BLM) and actively loaded SR vesicles
Comparison
Ryanodine (nanomolar to micromolar concentrations) vs Control conditions (absence of ryanodine)
Design
Preclinical
Authors
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Animal findings on ryanodine channel states should not change practice; leaves open translation to human cardiac models.
This preclinical study demonstrates that ryanodine interacts with multiple effector sites to stabilize four distinct conformational states of the skeletal muscle calcium release channel.
Buck et al. (1992) studied this question.
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