What question did this study set out to answer?

To establish an expanded, unambiguous locomotor rating scale that standardizes open-field functional assessments across different spinal cord injury laboratories.

February 1, 1995Journal of Neurotrauma

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

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Authors

DBD. Michele BassoThe Ohio State University MBMichael S. BeattieSan Francisco General Hospital JBJacqueline C. BresnahanUniversity of California, San Francisco

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Implication

Animal study demonstrates an expanded open-field locomotor rating scale in contused rats, highlighting improved precision and interlaboratory reliability for spinal cord injury research.

Key Points

To establish an expanded, unambiguous locomotor rating scale that standardizes open-field functional assessments across different spinal cord injury laboratories.
Adult rats (n = 85) received thoracic T7–9 spinal cord contusions using either an electromagnetic impactor or a weight-drop device.
Locomotion was evaluated in an open field prior to surgery, on postoperative day 1 or 2, and monitored longitudinally for up to 10 weeks.
Sequential behavioral milestones were categorized and ranked into the Basso, Beattie, Bresnahan (BBB) Locomotor Rating Scale to assess motor recovery.
The BBB scale distinguished functional recovery trajectories produced by different injury severities and correlated with tissue preservation at the injury epicenter.
Interrater reliability evaluations confirmed that examiners across varying degrees of testing experience generated consistent and reproducible behavioral scores.

Cite This Study

Basso et al. (1995) studied this question.

synapsesocial.com/papers/69d7c6fe6c394ad7d0bedae2 https://doi.org/10.1089/neu.1995.12.1

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Implication

Animal study demonstrates an expanded open-field locomotor rating scale in contused rats, highlighting improved precision and interlaboratory reliability for spinal cord injury research.

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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