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Does chronic nitric oxide synthase inhibition with L-NAME induce hypertrophy and remodeling in cerebral arterioles of Wistar-Kyoto rats?
Does chronic nitric oxide synthase inhibition with L-NAME induce hypertrophy and remodeling in cerebral arterioles of Wistar-Kyoto rats?
Genetic factors in WKY and SHRSP rats may contribute to vascular inward remodeling during chronic hypertension induced by NOS inhibition.
Does not alter clinical hypertension management; leaves open genetic contributions to remodeling in NOS-inhibition models.
Cerebral arterioles undergo hypertrophy and remodeling in WKY with L-NAME-induced hypertension. These findings suggest that genetic factors present in WKY and SHRSP may play a role in the development of vascular inward remodeling during chronic hypertension in rats.
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Chillon et al. (2004) studied this question.
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