April 1, 1975The Journal of Clinical Endocrinology & Metabolism
Suppression of Renin and Aldosterone by Small Amounts of DOCA in Normal Man
Why the study?
Does administration of small amounts of desoxycorticosterone acetate (DOCA) suppress renin and aldosterone in normal subjects?
Population
3 normal subjects
Comparison
Small amounts of desoxycorticosterone acetate… vs Baseline (before administration of DOCA)
Design
Other
Follow-up
13 days
Authors
Discussion
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Implication
May indicate inappropriately normal aldosterone in low-renin hypertension; hypothesis-generating and requires patient confirmation.
Structured PICO
Does administration of small amounts of desoxycorticosterone acetate (DOCA) suppress renin and aldosterone in normal subjects?
P
Population
3 normal subjects
I
Intervention
Small amounts of desoxycorticosterone acetate (DOCA) administered for 13 days on a high and low salt diet
C
Comparator
Baseline (before administration of DOCA)
O
Outcome
Response of 2-h upright plasma renin activity (PRA), plasma aldosterone concentration (PA), urinary aldosterone excretion (UA), and extracellular fluid volume (ECFV)surrogate
Administration of DOCA in normal subjects suppresses renin and aldosterone, suggesting that in low renin hypertension, normal levels of aldosterone are inappropriately elevated relative to low renin.
Cite This Study
Shade et al. (1975) studied this question.