What question did this study set out to answer?

Assess the effect of intrahepatic cholestasis of pregnancy on adverse perinatal outcomes over an eight-year observation period.

February 19, 2020PLoS ONEOpen Access

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study

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Authors

CAChloé ArthuisHôpital Necker-Enfants Malades CDC. DiguistoCentre Hospitalier Universitaire de Tours HLHenri LorphelinUniversité Paris Cité

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Implication

Case-control study reveals higher rates of respiratory distress syndrome and neonatal morbidity in intrahepatic cholestasis, highlighting the need for targeted perinatal care.

Key Points

Assess the effect of intrahepatic cholestasis of pregnancy on adverse perinatal outcomes over an eight-year observation period.
Conducted an 8-year case-control study assessing neonates delivered to mothers with intrahepatic cholestasis versus controls.
Controlled for confounding factors using multivariable adjustment.
Infants in the cholestasis group experienced significantly higher rates of respiratory distress syndrome after adjustment for confounders.
Overall neonatal morbidity was elevated among infants born to mothers with intrahepatic cholestasis compared to controls.

Cite This Study

Arthuis et al. (2020) studied this question.

synapsesocial.com/papers/69d7c93ba2a48916bbbed915 https://doi.org/10.1371/journal.pone.0228213

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Implication

Case-control study reveals higher rates of respiratory distress syndrome and neonatal morbidity in intrahepatic cholestasis, highlighting the need for targeted perinatal care.

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study

Discussion

Member takes

Implication

Key Points

Cite This Study

Perinatal outcomes of intrahepatic cholestasis during pregnancy: An 8-year case-control study

Discussion

Member takes

Implication

Key Points

Cite This Study

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