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October 9, 2002New England Journal of Medicine

Helicobacter pyloriInfection

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Authors

SSSebastian SuerbaumLMU KlinikumPMPierre MichettiUniversity Hospital of Lausanne

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Implication

Narrative review reveals mechanisms, diagnostics, and therapies for Helicobacter pylori infection in humans, highlighting improved clinical management of gastroduodenal disease.

Key Points

  • Synthesize clinical and epidemiological evidence regarding Helicobacter pylori transmission, its pathogenic role in upper gastrointestinal disorders, and current therapeutic strategies.
  • Narrative review summarizing two decades of research on Helicobacter pylori transmission and pathogenesis.
  • Qualitative evaluation of standard diagnostic methods, treatment indications, and clinical measures of therapeutic efficacy.
  • Helicobacter pylori infection is identified as a widespread human bacterial pathogen that directly drives the pathogenesis of upper gastrointestinal tract conditions.
  • The identification of Helicobacter pylori fundamentally altered clinical standards for diagnosing and managing gastroduodenal diseases through targeted eradication therapy.

Cite This Study

Suerbaum et al. (2002) studied this question.

synapsesocial.com/papers/69d7c9d23b601d7be3ae2f2ehttps://doi.org/10.1056/nejmra020542
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Randomized Controlled Trial of an Enhanced Patient Compliance Program for Helicobacter pylori Therapy1999 · 116 citations
  2. 2Expression of Interleukin‐18, a Th1 Cytokine, in Human Gastric Mucosa Is Increased inHelicobacter pyloriInfection2001 · 94 citations
  3. 3Autoantibodies to Gastric Mucosa in Helicobacter pylori Infection1997 · 66 citations
  4. 4Risk Factors for Helicobacter pylori Resistance in the United States: The Surveillance of H. pylori Antimicrobial Resistance Partnership (SHARP) Study, 1993–19992002 · 226 citations