The 3,3'-pyrrolidinyl-spirooxindole unit is a privileged heterocyclic motif that forms the core of a large family of alkaloid natural products with strong bioactivity profiles and interesting structural properties. Significant recent advances in the synthesis of this fused heterocyclic system have led to intense interest in the development of related compounds as potential medicinal agents or biological probes.
No takes yet. Share an insight, caveat, or question.
Galliford et al. (2007) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: