April 1, 1998Biochemical JournalOpen Access

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

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Why the study?

Does Apolipoprotein J promote cholesterol efflux from macrophage-foam cells?

Structured PICO

Does Apolipoprotein J promote cholesterol efflux from macrophage-foam cells?

Population

Mouse peritoneal macrophages (including from apo E-null mice) incubated with acetylated low-density lipoprotein (AcLDL) to produce foam cells

Intervention

Physiological concentrations of purified Apolipoprotein J (apo J)

Comparator

Apolipoprotein A-I (apo A-I) as a reference promoter of cholesterol efflux

Outcome

Cholesterol export/efflux from foam cellssurrogate

Apolipoprotein J promotes cholesterol efflux from macrophage-foam cells, indicating a potential anti-atherogenic role in cellular cholesterol homeostasis.

Discussion

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Implication

Supports apo J in foam cell cholesterol export; hypothesis-generating for anti-atherogenic mechanisms in humans.

Cite This Study

Gelissen et al. (1998) studied this question.

synapsesocial.com/papers/69d7ca23f39344339dd184f2 https://doi.org/10.1042/bj3310231

View Full Paper

Ask AI

Bookmark

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

Structured PICO

Discussion

Implication

Cite This Study

Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function?

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider