Why the study?
Do natriuretic peptides stimulate lipolysis in human adipocytes?
Population
Human isolated fat cells and abdominal subcutaneous adipose tissue of healthy subjects
Comparison
Natriuretic peptides (ANP, BNP, CNP) vs Isoproterenol and baseline/control
Design
Preclinical
Authors
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Hypothesis-generating for natriuretic peptide lipolysis via cGMP; leaves open human adipocyte validation and metabolic relevance.
Do natriuretic peptides stimulate lipolysis in human adipocytes?
Natriuretic peptides stimulate lipolysis in human adipose tissue via a novel cGMP-dependent pathway, independent of cAMP production.
Sengenès et al. (2000) studied this question.
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