April 22, 2016Open Access

Depression as a Risk Factor for the Initial Presentation of Twelve Cardiac, Cerebrovascular, and Peripheral Arterial Diseases: Data Linkage Study of 1.9 Million Women and Men

MDMarina DaskalopoulouUniversity College London JGJulie GeorgeBeaumont Hospital, Troy KWKate WaltersUniversity College London

Structured PICO

Does depression increase the risk of the initial presentation of cardiac, cerebrovascular, and peripheral arterial diseases in healthy women and men?

Population

1.9 million women and men (healthy populations)

Intervention

Depression (assessed as a risk factor)

Outcome

Initial presentation of twelve cardiac, cerebrovascular, and peripheral arterial diseaseshard clinical

Depression is a broad, non-specific risk factor for the initial presentation of multiple cardiovascular, cerebrovascular, and peripheral arterial diseases.

Abstract

Depression was prospectively associated with cardiac, cerebrovascular, and peripheral diseases, with no evidence of disease specificity. Further research is needed in understanding the specific pathophysiology of heart and vascular disease triggered by depression in healthy populations.

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