Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies
Why the study?
Is depression an independent aetiologic and prognostic factor for coronary heart disease?
Population
146,538 participants across 54 observational studies
Design
Meta-analysis
Authors
Discussion
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Implication
The independent role of depression as a risk factor for coronary heart disease remains unestablished due to confounding by conventional risk factors and disease severity in existing observational studies.
Key Points
- To assess whether depression should be considered an independent risk factor for coronary heart disease (CHD).
- Conducted a meta-analysis of 54 observational studies involving 146,538 participants.
- Analyzed 6,362 events related to coronary heart disease and depression.
- Reviewed the impact of conventional risk factors and severity of coronary disease on the outcomes.
- Depression's status as an independent risk factor for CHD remains unclear due to bias in the existing studies.
- Incomplete adjustments for traditional risk factors were found to affect the interpretation of the data.
Structured PICO
Is depression an independent aetiologic and prognostic factor for coronary heart disease?
P
Population
146,538 participants across 54 observational studies
I
Intervention
Depression
O
Outcome
Coronary heart disease eventshard clinical
The independent role of depression as a risk factor for coronary heart disease remains unestablished due to confounding by conventional risk factors and disease severity in existing observational studies.
Limitations
- incomplete and biased availability of adjustment for conventional risk factors and severity of coronary disease
Cite This Study
Nicholson et al. (2006) studied this question.