What question did this study set out to answer?

Determine whether genetically engineered indica rice can reach target nutritional thresholds for iron and zinc under actual field conditions without compromising yield or grain quality.

January 25, 2016Scientific ReportsOpen Access

Biofortified indica rice attains iron and zinc nutrition dietary targets in the field

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Determine whether genetically engineered indica rice can reach target nutritional thresholds for iron and zinc under actual field conditions without compromising yield or grain quality.
Screened 1,689 transgenic IR64 events expressing rice nicotianamine synthase (OsNAS2) and soybean ferritin (SferH-1) for insert integrity and agronomic traits.
Conducted field evaluations of selected transgenic lines across two countries to quantify polished grain iron and zinc concentrations.
Evaluated endosperm nutrient distribution via X-ray fluorescence imaging, iron bioavailability using Caco-2 cell assays, and tested for heavy metal contamination.
Transgenic event NASFer-274 achieved 15 μg g⁻¹ iron and 45.7 μg g⁻¹ zinc in polished grain under field conditions, exceeding the HarvestPlus breeding targets of 13 μg g⁻¹ Fe and 28 μg g⁻¹ Zn.
The line exhibited a single-locus insertion with stable expression across genetic backgrounds, demonstrating no yield penalty, no altered grain quality, and no detectable toxic heavy metals.
Caco-2 cell assays confirmed that the accumulated iron is bioavailable, while X-ray fluorescence validated enrichment within the endosperm.

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Implication

Field trial demonstrates targeted iron and zinc biofortification in transgenic indica rice, indicating a viable strategy to alleviate global micronutrient malnutrition.

Cite This Study

Trijatmiko et al. (2016) studied this question.

synapsesocial.com/papers/69d7cc7861e2ce1627d180ed https://doi.org/10.1038/srep19792

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Implication

Field trial demonstrates targeted iron and zinc biofortification in transgenic indica rice, indicating a viable strategy to alleviate global micronutrient malnutrition.

Biofortified indica rice attains iron and zinc nutrition dietary targets in the field

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Discussion

Implication

Cite This Study

Biofortified indica rice attains iron and zinc nutrition dietary targets in the field

Key Points

Discussion

Implication

Cite This Study

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