Insulin Receptor Signaling in Normal and Insulin-Resistant States
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Discussion
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Implication
Review details insulin receptor signaling pathways across metabolic tissues, highlighting therapeutic targets for obesity-induced insulin resistance and type-2 diabetes.
Key Points
- To review the molecular mechanisms governing insulin receptor signaling in healthy homeostasis and examine how these pathways malfunction during insulin-resistant states.
- Synthesized molecular and physiological evidence regarding insulin signaling cascades in the liver, skeletal muscle, and adipose tissue.
- Evaluated pathway modulation across fed and fasted states, including positive and negative regulators, protein isoform interactions, and the roles of obesity and genetic mutations.
- Tissue-specific regulators and protein isoform interactions precisely orchestrate transitions in glucose, lipid, and energy homeostasis between fed and fasted states.
- Pathological insulin resistance develops via diverse obesity-mediated mechanisms or, less commonly, from rare genetic mutations in the signaling pathway.
Cite This Study
Boucher et al. (2014) studied this question.