What question did this study set out to answer?

To re-evaluate and refine standardized clinical course descriptions and phenotypes of multiple sclerosis in light of advancements in disease understanding and pathology.

May 28, 2014NeurologyOpen Access

Defining the clinical course of multiple sclerosis

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Authors

FLFred LublinIcahn School of Medicine at Mount Sinai SRStephen C. ReingoldSt. Michael's Hospital JCJeffrey A. CohenCleveland Clinic

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Implication

Consensus framework proposes refined clinical course descriptors incorporating disease activity and progression in multiple sclerosis, improving trial design and treatment decisions.

Key Points

To re-evaluate and refine standardized clinical course descriptions and phenotypes of multiple sclerosis in light of advancements in disease understanding and pathology.
Convened by the International Advisory Committee on Clinical Trials of Multiple Sclerosis to review and update the 1996 consensus-derived clinical descriptors.
Assessed integration of clinical course features with emerging neuroimaging parameters and potential biological markers.
Identified a continuing lack of validated biological and imaging markers capable of independently separating clinical phenotypes.
Formulated refined descriptors that characterize phenotypes by incorporating measures of disease activity (relapse rates and imaging findings) alongside objective disease progression.
Established strategic research frameworks to guide the discovery and validation of objective markers for future phenotypic classifications.

Cite This Study

Lublin et al. (2014) studied this question.

synapsesocial.com/papers/69d7d386f39344339dd188ee https://doi.org/10.1212/wnl.0000000000000560

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Implication

Consensus framework proposes refined clinical course descriptors incorporating disease activity and progression in multiple sclerosis, improving trial design and treatment decisions.

Defining the clinical course of multiple sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Defining the clinical course of multiple sclerosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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