What question did this study set out to answer?

To compare bacterial communities between children with early childhood caries and caries-free controls using molecular identification techniques.

March 1, 2002Journal of Clinical MicrobiologyOpen Access

Molecular Analysis of Bacterial Species Associated with Childhood Caries

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Authors

MBMitzi R. Becker BPBruce J. PasterStatens Serum Institut ELEugene J. LeysThe Ohio State University

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Implication

Case-control study reveals distinct bacterial profiles associated with childhood tooth decay, indicating that complex microbial communities drive dental caries progression.

Key Points

To compare bacterial communities between children with early childhood caries and caries-free controls using molecular identification techniques.
Cloned and sequenced 16S ribosomal DNAs from one healthy subject and one subject with early childhood caries to identify novel species and uncultivated phylotypes.
Quantified 23 bacterial species or species groups using a reverse capture checkerboard assay in 30 subjects with caries and 30 healthy controls.
Identified ten novel bacterial phylotypes not previously linked to dental caries through 16S ribosomal DNA sequencing.
Found significant abundance differences across nine species: Streptococcus sanguinis was associated with health, whereas Actinomyces gerencseriae, Bifidobacterium, Streptococcus mutans, Veillonella, Streptococcus salivarius, Streptococcus constellatus, Streptococcus parasanguinis, and Lactobacillus fermentum were associated with caries.

Cite This Study

Becker et al. (2002) studied this question.

synapsesocial.com/papers/69d7d4b3ec32c73b01ae2da0 https://doi.org/10.1128/jcm.40.3.1001-1009.2002

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Implication

Case-control study reveals distinct bacterial profiles associated with childhood tooth decay, indicating that complex microbial communities drive dental caries progression.

Molecular Analysis of Bacterial Species Associated with Childhood Caries

Discussion

Member takes

Implication

Key Points

Cite This Study

Molecular Analysis of Bacterial Species Associated with Childhood Caries

Discussion

Member takes

Implication

Key Points

Cite This Study

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