What question did this study set out to answer?

To evaluate serum interleukin-6 levels in patients with systemic-onset juvenile rheumatoid arthritis and determine their association with disease activity, joint involvement, and thrombocytosis.

October 7, 1991Arthritis & Rheumatism

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

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Authors

FBFabrizio De BenedettiAstraZeneca (United Kingdom)MMMargherita MassaPoliclinico San Matteo Fondazione PRPiera RobbioniSan Raffaele University of Rome

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Implication

Observational study demonstrates elevated serum interleukin-6 correlates with joint disease and platelet counts in systemic juvenile rheumatoid arthritis, indicating a key pathogenic role.

Key Points

To evaluate serum interleukin-6 levels in patients with systemic-onset juvenile rheumatoid arthritis and determine their association with disease activity, joint involvement, and thrombocytosis.
Assayed 70 serum samples from 25 patients with systemic-onset juvenile rheumatoid arthritis alongside healthy age-matched controls.
Quantified interleukin-6 bioactivity using the B9 hybridoma cell line during active disease states and remission.
Serum interleukin-6 levels were markedly elevated during active disease (mean ± SD: 92.1 ± 75.1 hybridoma growth factor units/ml) compared to healthy controls (P < 0.00001), but normalized during clinical remission.
Interleukin-6 concentrations correlated significantly with the severity and extent of joint involvement (P < 0.001) and with elevated platelet counts (P < 0.05).

Cite This Study

Benedetti et al. (1991) studied this question.

synapsesocial.com/papers/69d7d567a2a48916bbbedfbb https://doi.org/10.1002/art.1780340912

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Implication

Observational study demonstrates elevated serum interleukin-6 correlates with joint disease and platelet counts in systemic juvenile rheumatoid arthritis, indicating a key pathogenic role.

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

Correlation of Serum Interleukin‐6 Levels with Joint Involvement and Thrombocytosis in Systemic Juvenile Rheumatoid Arthritis

Discussion

Member takes

Implication

Key Points

Cite This Study

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