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August 28, 2008Proceedings of the National Academy of SciencesOpen Access

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

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Authors

DZDawei ZhangMonash University MalaysiaRGRita GarutiHumanitas UniversityWTWan-Jin TangMcDermott International (United States)

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Zhang et al. (2008) studied this question.

synapsesocial.com/papers/69d7d5a6a2a48916bbbee03ahttps://doi.org/10.1073/pnas.0806312105
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Binding of Proprotein Convertase Subtilisin/Kexin Type 9 to Epidermal Growth Factor-like Repeat A of Low Density Lipoprotein Receptor Decreases Receptor Recycling and Increases Degradation2007 · 799 citations
  2. 2Secreted PCSK9 promotes LDL receptor degradation independently of proteolytic activity2007 · 150 citations
  3. 3Catalytic Activity Is Not Required for Secreted PCSK9 to Reduce Low Density Lipoprotein Receptors in HepG2 Cells2007 · 281 citations
  4. 4Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice1998 · 672 citations
  5. 5Immunologic cross-reactivity of the low density lipoprotein receptor from bovine adrenal cortex, human fibroblasts, canine liver and adrenal gland, and rat liver.1981 · 68 citations