What question did this study set out to answer?

Review the cellular and molecular mechanisms through which amino acids influence immune responses and evaluate dietary supplementation strategies for preventing and treating infectious diseases.

April 3, 2007British Journal Of NutritionOpen Access

Amino acids and immune function

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Authors

PLPeng Li YYYulong Yin DLDefa Li

Discussion

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Overview

Narrative review reveals enhanced immune cell activity and reduced mortality in malnourished animals and humans, highlighting the clinical potential of targeted amino acid support.

Key Points

Review the cellular and molecular mechanisms through which amino acids influence immune responses and evaluate dietary supplementation strategies for preventing and treating infectious diseases.
Synthesized molecular, biochemical, and physiological findings on amino acid metabolism in leukocytes, including effects on cell signaling, gene expression, and redox balance.
Assessed experimental and clinical evidence regarding dietary supplementation of key amino acid prototypes, primarily arginine, glutamine, and cysteine precursors, across animal and human models of malnutrition.
Amino acids regulate the activation and proliferation of T lymphocytes, B lymphocytes, natural killer cells, and macrophages, as well as the production of antibodies and cytokines.
Dietary supplementation with arginine, glutamine, or cysteine precursors improves immune status and reduces morbidity and mortality under conditions of malnutrition and infection.
Nutrient imbalances and antagonism among amino acids can impair overall utilization, necessitating balanced enteral or parenteral formulation strategies based on individual metabolic status.

Cite This Study

Li et al. (2007) studied this question.

synapsesocial.com/papers/69d7d5b5a2a48916bbbee06c https://doi.org/10.1017/s000711450769936x

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April 3, 2007British Journal Of NutritionOpen Access

Amino acids and immune function

View Full Paper

Ask AI

Bookmark

Authors

PLPeng Li YYYulong Yin DLDefa Li

Discussion

Member takes

Overview

Narrative review reveals enhanced immune cell activity and reduced mortality in malnourished animals and humans, highlighting the clinical potential of targeted amino acid support.

Key Points

Review the cellular and molecular mechanisms through which amino acids influence immune responses and evaluate dietary supplementation strategies for preventing and treating infectious diseases.
Synthesized molecular, biochemical, and physiological findings on amino acid metabolism in leukocytes, including effects on cell signaling, gene expression, and redox balance.
Assessed experimental and clinical evidence regarding dietary supplementation of key amino acid prototypes, primarily arginine, glutamine, and cysteine precursors, across animal and human models of malnutrition.
Amino acids regulate the activation and proliferation of T lymphocytes, B lymphocytes, natural killer cells, and macrophages, as well as the production of antibodies and cytokines.
Dietary supplementation with arginine, glutamine, or cysteine precursors improves immune status and reduces morbidity and mortality under conditions of malnutrition and infection.
Nutrient imbalances and antagonism among amino acids can impair overall utilization, necessitating balanced enteral or parenteral formulation strategies based on individual metabolic status.

Cite This Study

Li et al. (2007) studied this question.

synapsesocial.com/papers/69d7d5b5a2a48916bbbee06c https://doi.org/10.1017/s000711450769936x

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