What question did this study set out to answer?

Identify molecular pathways and cellular drivers underlying primary Sjögren's syndrome pathology using an integrative, multi-layered systems approach.

May 19, 2017Annals of the Rheumatic DiseasesOpen Access

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

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Authors

STShinya TasakiRush University Medical Center KSKatsuya SuzukiKeio University ANAyumi NishikawaTokai University

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Implication

Multiomic analysis reveals convergence of molecular disease signatures onto cytotoxic CD8 T cells in primary Sjögren's syndrome, highlighting key cellular drivers of autoimmune pathology.

Key Points

Identify molecular pathways and cellular drivers underlying primary Sjögren's syndrome pathology using an integrative, multi-layered systems approach.
Conducted an integrative multiomics investigation across biological layers to profile molecular and cellular signatures in primary Sjögren's syndrome.
Identified distinct multiomic gene signatures deeply linked to primary Sjögren's syndrome disease pathology.
Demonstrated that integrated multi-layered molecular networks converge directly on cytotoxic CD8 T cell involvement.

Cite This Study

Tasaki et al. (2017) studied this question.

synapsesocial.com/papers/69d7d728ec32c73b01ae2e81 https://doi.org/10.1136/annrheumdis-2016-210788

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Implication

Multiomic analysis reveals convergence of molecular disease signatures onto cytotoxic CD8 T cells in primary Sjögren's syndrome, highlighting key cellular drivers of autoimmune pathology.

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiomic disease signatures converge to cytotoxic CD8 T cells in primary Sjögren's syndrome

Discussion

Member takes

Implication

Key Points

Cite This Study

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