Preclinical study demonstrates shear-thinning and glucose-responsive protein release from self-healing hydrogels, indicating potential for smart injectable drug delivery.
Dynamically restructuring pH-responsive hydrogels are synthesized, employing dynamic covalent chemistry between phenylboronic acid and cis-diol modified poly(ethylene glycol) macromonomers. These gels display shear-thinning behavior, followed by a rapid structural recovery (self-healing). Size-dependent in vitro controlled and glucose-responsive release of proteins from the hydrogel network, as well as the biocompatibility of the gels, are evaluated both in vitro and in vivo.
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Yesilyurt et al. (2015) studied this question.
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