Roles of epithelial cell-derived periostin in TGF-β activation, collagen production, and collagen gel elasticity in asthma

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Structured PICO

Population

Bronchial epithelial cells of asthmatic subjects, primary human bronchial epithelial cells, and airway fibroblasts

Intervention

Periostin stimulation, periostin overexpression, and mixing recombinant periostin with type 1 collagen

Outcome

TGF-beta signaling pathway activation, type 1 collagen secretion, and elastic modulus of collagen gelsurrogate

Epithelial cell-derived periostin plays a key role in TGF-beta activation and collagen gel elasticity in asthma.

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Periostin-MMP-TGF-β axis merits target validation in asthma; animal findings leave open human translation and therapeutic testing.

Sidhu et al. (2010) studied this question.

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