Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score
Randomized trial validates a risk-stratification score for hospitalized covid-19 patients, demonstrating accurate prediction of in-hospital mortality to guide clinical decisions.
Key Points
To develop and validate a pragmatic risk-stratification score (the 4C Mortality Score) to predict in-hospital mortality among patients admitted with covid-19.
Interventional trial framework registered under ISRCTN66726260.
Utilized data collected through the ISARIC WHO Clinical Characterisation Protocol to establish and validate risk assessment metrics.
The 4C Mortality Score effectively categorizes hospitalized covid-19 patients into distinct mortality risk groups based on clinical and physiological variables.
The risk stratification model demonstrates strong discrimination and calibration across validation cohorts for predicting in-hospital mortality.