What question did this study set out to answer?

To review the underlying molecular mechanisms, genetic susceptibility, and clinical pathology of age-related hearing loss and its relationship with systemic comorbidities.

October 5, 2018Cold Spring Harbor Perspectives in MedicineOpen Access

Age-Related Hearing Loss

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To review the underlying molecular mechanisms, genetic susceptibility, and clinical pathology of age-related hearing loss and its relationship with systemic comorbidities.
Narrative synthesis of recent evidence from human and animal studies investigating progressive auditory decline.
Evaluation of clinical associations with non-auditory outcomes, including frailty, depression, and cognitive deterioration.
Characterizes age-related auditory decline as a primary sensory deficit tightly associated with increased risks of social isolation, falls, depression, and dementia.
Identifies major gaps in the molecular understanding of inner-ear aging while highlighting sensory intervention as a feasible target to mitigate dementia risk.

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Implication

Review uncovers systemic impacts and genetic mechanisms of age-related hearing loss in older adults, highlighting its role as a modifiable target against dementia.

Cite This Study

Bowl et al. (2018) studied this question.

synapsesocial.com/papers/69d7da305c3030ff03d17e4f https://doi.org/10.1101/cshperspect.a033217

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Implication

Review uncovers systemic impacts and genetic mechanisms of age-related hearing loss in older adults, highlighting its role as a modifiable target against dementia.

Age-Related Hearing Loss

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Discussion

Implication

Cite This Study

Age-Related Hearing Loss

Key Points

Discussion

Implication

Cite This Study

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