What question did this study set out to answer?

To review synthesis methods, structural factors governing catalytic performance, and emerging biomedical applications of single-atom nanozymes as robust alternatives to natural enzymes.

February 11, 2023Advanced Materials

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

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Authors

CPChao PengUniversity of Science and Technology of China RPRuoyu PangUniversity of Science and Technology of China JLJing LiUniversity of Science and Technology of China

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Implication

Review demonstrates synthetic strategies and structural tuning for single-atom nanozymes in biological systems, highlighting their potential as precise mimics of natural enzymes.

Key Points

To review synthesis methods, structural factors governing catalytic performance, and emerging biomedical applications of single-atom nanozymes as robust alternatives to natural enzymes.
Reviewed bottom-up and top-down fabrication strategies for anchoring isolated metal atoms onto supportive nanomaterial scaffolds.
Analyzed structural determinants of catalytic activity, including the central metal atom identity, coordination number, heteroatom doping, and metal-support interactions.
Summarized experimental bioapplications spanning biosensing, antibacterial and antiviral formulations, and targeted cancer therapeutics.
Single-atom nanozymes maximize atom utilization and feature well-defined active sites that overcome the heterogeneous activity of conventional nanomaterials.
Tailoring coordination geometries and metal-support electronic interactions substantially improves enzymatic catalytic selectivity and reaction rates across in vitro and in vivo models.
Critical translational hurdles persist regarding scalable synthesis, long-term stability in physiological environments, and comprehensive toxicity profiles.

Cite This Study

Peng et al. (2023) studied this question.

synapsesocial.com/papers/69d7dfa57392c8ce61bee095 https://doi.org/10.1002/adma.202211724

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Implication

Review demonstrates synthetic strategies and structural tuning for single-atom nanozymes in biological systems, highlighting their potential as precise mimics of natural enzymes.

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Discussion

Member takes

Implication

Key Points

Cite This Study

Current Advances on the Single‐Atom Nanozyme and Its Bioapplications

Discussion

Member takes

Implication

Key Points

Cite This Study

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