May 1, 2009Archives of General Psychiatry344 citations
View Full PaperWhite Matter Microstructural Integrity and Cognitive Function in a General Elderly Population
Structured PICO
Does measuring white matter microstructural integrity provide added value beyond macrostructural assessment for evaluating cognitive function in a general elderly population?
P
Population
General elderly population
I
Intervention
Measurement of white matter microstructural integrity
C
Comparator
Macrostructural assessment of white matter changes (white matter atrophy and white matter lesion volume)
O
Outcome
Cognitive functionsurrogate
Measuring white matter microstructural integrity provides added value beyond macrostructural assessment for evaluating the relationship between white matter and cognitive function in the elderly.
Abstract
Microstructural integrity of both white matter lesions and normal-appearing white matter is associated with cognitive function, regardless of white matter atrophy and white matter lesion volume. This suggests that measuring white matter integrity has added value beyond macrostructural assessment of white matter changes to study the relation between white matter and cognition.