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July 20, 1994JAMA

Users' Guides to the Medical Literature

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Authors

ALAndreas LaupacisGeneral Cardiology

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Implication

Clinical guide demonstrates evidence-based approaches to evaluate dementia in older adults, highlighting practical strategies for cognitive assessment and management.

Key Points

  • Provide clinicians with an evidence-based medicine framework to critically evaluate literature and guide diagnostic, prognostic, and management decisions in patients with cognitive decline.
  • Presents a clinical vignette of a 76-year-old woman evaluated with the Standardized Mini-Mental State Examination (scoring 18/30) and standard workups to rule out treatable causes of cognitive impairment.
  • Applies structured methodologies to formulate clinical questions, search medical literature, and critically appraise evidence relevant to suspected dementia.
  • Characterizes probable Alzheimer's disease based on progressive cognitive decline, behavioral changes including agitation and paranoia, and exclusion of secondary etiologies.
  • Outlines practical steps for integrating critical literature appraisal into everyday clinical discussions regarding prognosis, therapy, and patient autonomy.

Cite This Study

Andreas Laupacis (1994) studied this question.

synapsesocial.com/papers/69d7e7e605ee2ba81dbee850https://doi.org/10.1001/jama.1994.03520030076032
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epidemiologic assessment of chronic atrial fibrillation and risk of stroke1978 · 1,549 citations
  2. 2Users' Guides to the Medical Literature1994 · 311 citations
  3. 3AN APPROACH TO LONGITUDINAL STUDIES IN A COMMUNITY: THE FRAMINGHAM STUDY1963 · 563 citations
  4. 4The Art and Science of Nondisease1965 · 106 citations
  5. 5Inclusion of Women in Clinical Trials -- Policies for Population Subgroups1993 · 129 citations