The tendency for nanoparticles to accumulate in tumor regions as a result of the enhanced permeability and retention effect has proven to be an advantageous feature for delivery of anti-cancer therapeutics and contrast agents for cancer detection. However, efficient drug delivery is dependent on nanoparticle stability in the circulation, accumulation and penetration into tumor tissues, and release of drugs to their sites of activity. Nanoparticles can be engineered bearing multiple functionalities to achieve optimal therapeutic and diagnostic effects. This review examines functionalities engineered into nanoparticles, including active targeting, triggered release of contents, and imaging capabilities.
No takes yet. Share an insight, caveat, or question.
Loomis et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: