Why the study?
Does the use of specific cell lines (HELF WI-38 and HeLa-I) improve the isolation of human rhinovirus from clinical samples?
Population
Nasal washings and nasal and pharyngeal swabs from volunteers with naturally acquired colds
Comparison
Human embryonic lung fibroblast strain WI-38 and… vs Other cell types used for HRV isolation
Design
Preclinical
Authors
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May enhance HRV recovery in diagnostic labs; hypothesis-generating and requires prospective validation before routine use.
Does the use of specific cell lines (HELF WI-38 and HeLa-I) improve the isolation of human rhinovirus from clinical samples?
A combination of different HRV-susceptible cell lines, specifically HELF WI-38 and HeLa-I, provides the best approach for the recovery of human rhinovirus from clinical samples.
Arruda et al. (1996) studied this question.
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