What question did this study set out to answer?

To review the mechanisms through which intestinal epithelial cells detect commensal microbes and sustain host-microbial symbiosis.

September 8, 2010Proceedings of the National Academy of SciencesOpen Access

Epithelial crosstalk at the microbiota–mucosal interface

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To review the mechanisms through which intestinal epithelial cells detect commensal microbes and sustain host-microbial symbiosis.
Synthesized molecular and immunological literature examining pattern recognition receptor signaling in enterocytes, goblet cells, and endocrine cells.
Evaluated functional phenotypes from knockout mouse models investigating epithelial Toll-like receptor deficiency.
Intestinal epithelial cells employ Toll-like receptors and nucleotide oligomerization domain-like receptors to drive barrier maintenance and secretory IgA production.
Epithelial cytokine secretion shapes the activity of dendritic cells, macrophages, and lymphocytes to establish an immunosuppressive tone against harmless luminal antigens.
Knockout mouse models demonstrate that epithelial Toll-like receptor signaling is necessary for gut homeostasis and protects against unrestrained mucosal inflammation.

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Implication

Review reveals how epithelial pattern recognition receptors preserve mucosal barrier integrity and immune tolerance, highlighting pathways preventing gut inflammation.

Cite This Study

Wells et al. (2010) studied this question.

synapsesocial.com/papers/69d7f0c611d83f35e5ae35fe https://doi.org/10.1073/pnas.1000092107

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Implication

Review reveals how epithelial pattern recognition receptors preserve mucosal barrier integrity and immune tolerance, highlighting pathways preventing gut inflammation.

Epithelial crosstalk at the microbiota–mucosal interface

Key Points

Discussion

Implication

Cite This Study

Epithelial crosstalk at the microbiota–mucosal interface

Key Points

Discussion

Implication

Cite This Study

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