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Observational study reveals perioperative GLP-1 dynamics and phospholipid shifts in hepatectomy patients, highlighting their link to posthepatectomy liver failure.
Significant metabolic changes occur during human liver resection, particularly in phospholipid metabolism, along with distinct perioperative dynamics of GLP-1 and GLP-2, closely linked to PHLF and independent of the histological phenotype of MASLD. Additionally, we provide exploratory results on the predictive value of GLP-1 for PHLF, emphasizing a holistic model of liver function assessment highlighting the metabolic component of human liver regeneration.
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Ammann et al. (2025) studied this question.
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