Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Claire Conche; Fabian Finkelmeier; Marina Pešić; Adele M. Nicolas; Tim W. Böttger; Kilian B. Kennel; Dominic Denk; Fatih Ceteci; Kathleen Mohs; Esther Engel; Özge Canli; Yasamin Dabiri; Kai‐Henrik Peiffer; Stefan Zeuzem; Gabriela Salinas; Thomas Longerich; Huan Yang; Florian R. Greten

doi:10.1136/gutjnl-2022-327909

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Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases.

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Conche et al. (2023) studied this question.

synapsesocial.com/papers/69d7f1c95c3030ff03d1881b https://doi.org/10.1136/gutjnl-2022-327909

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Abstract

This is the authors' abstract. We don't add key points for this paper.

Our data highlight a context-specific ferroptosis-induced immune response that could be therapeutically exploited for the treatment of primary liver tumours and liver metastases.

Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Abstract

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Discussion

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Combining ferroptosis induction with MDSC blockade renders primary tumours and metastases in liver sensitive to immune checkpoint blockade

Abstract

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