Genetic knockout study demonstrates increased trabecular bone mass via reduced osteoclast differentiation, indicating interleukin-11 directly regulates bone remodeling.
IL-11 signaling is clearly required for normal bone turnover and normal trabecular bone mass, yet not for the effects of estradiol or estrogen deficiency on the skeleton. In the absence of IL-11Ralpha, increased trabecular bone mass seems to result from a cell lineage-autonomous reduction in osteoclast differentiation, suggesting a direct effect of IL-11 on osteoclast precursors. The effects of IL-11Ralpha deletion on the skeleton are not mediated or compensated for by changes in IL-6 signaling.
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Sims et al. (2005) studied this question.
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