What question did this study set out to answer?

To resolve conflicting findings regarding whether IL-17A signaling promotes or protects against bone loss in estrogen deficiency-induced osteoporosis.

March 30, 2020Scientific ReportsOpen Access

Interleukin 17A: a Janus-faced regulator of osteoporosis

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Authors

JSJulia M. SchefflerNational Academy of Medicine LGLouise GrahnemoUniversity of Gothenburg CECecilia EngdahlSwedish Defence Research Agency

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Implication

Preclinical study reveals distinct roles for IL-17A in cortical versus trabecular bone loss in mice, suggesting compartment-specific targets for postmenopausal osteoporosis.

Key Points

To resolve conflicting findings regarding whether IL-17A signaling promotes or protects against bone loss in estrogen deficiency-induced osteoporosis.
Examined bone remodeling after ovariectomy (OVX) in wild-type mice compared with IL-17A knock-out mice.
Evaluated cortical and trabecular bone compartments, bone-turnover rates, leptin levels, and bone marrow adipose tissue expansion.
Loss of IL-17A prevented ovariectomy-induced cortical bone loss but did not prevent trabecular bone loss.
Ovariectomized IL-17A knock-out mice demonstrated elevated leptin levels, increased bone marrow adipose tissue expansion, and decreased bone turnover compared to ovariectomized wild-type controls.

Cite This Study

Scheffler et al. (2020) studied this question.

synapsesocial.com/papers/69ded4ae4838c5c0bab0d2c6 https://doi.org/10.1038/s41598-020-62562-2

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Implication

Preclinical study reveals distinct roles for IL-17A in cortical versus trabecular bone loss in mice, suggesting compartment-specific targets for postmenopausal osteoporosis.

Interleukin 17A: a Janus-faced regulator of osteoporosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Interleukin 17A: a Janus-faced regulator of osteoporosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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