What question did this study set out to answer?

To outline the protocol and design framework of INCEPT, an adaptive platform trial designed to assess multiple simultaneous treatments in adult intensive care unit patients.

March 14, 2025Acta Anaesthesiologica ScandinavicaOpen Access

INCEPT: The Intensive Care Platform Trial—Design and protocol

View Full Paper

Ask AI

Bookmark

Authors

AGAnders GranholmUniversity of Copenhagen MMMorten Hylander MøllerUniversity of Copenhagen BKBenjamin Skov Kaas‐HansenCopenhagen University Hospital

Discussion

Member takes

Implication

Trial protocol describes an adaptive platform design evaluating multiple critical care therapies in adult intensive care patients, suggesting accelerated translation of evidence into practice.

Key Points

To outline the protocol and design framework of INCEPT, an adaptive platform trial designed to assess multiple simultaneous treatments in adult intensive care unit patients.
Pragmatic, flexible platform trial architecture established across adult intensive care settings.
Employs an adaptive design framework that uses accumulating clinical data to inform and optimize treatment allocations for future participants.
Establishes an infrastructure aimed at providing high-certainty comparative evidence for diverse critical care interventions.
Designed to directly inform clinical management guidelines and improve long-term patient-important clinical outcomes.

Cite This Study

Granholm et al. (2025) studied this question.

synapsesocial.com/papers/69d806aa45af6083e6ae2a1f https://doi.org/10.1111/aas.70023

View Full Paper

Ask AI

Bookmark

Implication

Trial protocol describes an adaptive platform design evaluating multiple critical care therapies in adult intensive care patients, suggesting accelerated translation of evidence into practice.

INCEPT: The Intensive Care Platform Trial—Design and protocol

Discussion

Member takes

Implication

Key Points

Cite This Study

INCEPT: The Intensive Care Platform Trial—Design and protocol

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider